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Crohn’s Disease


• Challenging to treat • Trials of therapy
• Intralesional corticosteroids such as triamcinolone acetonide 5–10 mg/mL; inject 1–3 mL per session with sessions at 3–4 wk intervals
• Systemic antibiotic: tetracycline 500 mg tid • Systemic corticosteroid: prednisone 5 mg tablets #80
– Take each morning with breakfast for 16 d as 8/d × 4 d, 6/d × 4 d, 4/d × 4 d, 2/d × 4 d, stop

– Will reduce disease activity as topical corticosteroids or systemic nonsteroidal anti-inflammatory drugs (NSAIDs) are started
• Dapsone 25 mg tablets – Check baseline CBC, liver function tests, urinalysis, and
glucose-6-phosphate red blood cell enzyme level before treatment.
– Take each morning with breakfast, 1 × 3 d, 2 × 3 d, 3 × 3 d, 4 × 7 d, and 5 daily thereafter
– Check CBC and liver function every month for 3 mo, then every 3 mo thereafter.
– Use for long-term control of disease