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Melkersson-Rosenthal Syndrome


• See “Fissured Tongue.” • Orofacial granulomatosis—see “Cheilitis Granulomatosa”
Nevus • All pigmented nevi should be excised, if reasonable from a

surgical point of view. Pemphigoid
• Refer to a dermatologist or an ophthalmologist, depending on organ involvement, for ongoing care, which may include systemic immunosuppressive and/or anti-inflammatory drugs.
• For localized oral pemphigoid/gingival pemphigoid, apply topical therapy: fluocinonide 0.05% gel/cream 60 g • Apply to early lesions after meals and at bedtime. • Do not apply to ulcers. • May be used for 1–2 h with mouthguard for occlusive therapy
• Systemic therapy for severe, chronic disease • Prednisone 5 mg tablets #80
– Take each morning with breakfast for 16 d as 8/d × 4 d, 6/d × 4 d, 4/d × 4 d, 2/d × 4 d, stop
– Will reduce disease activity as topical corticosteroids or systemic NSAIDs are started
• Dapsone 25 mg tablets – Check baseline CBC, liver function tests, urinalysis and
glucose-6-phosphate dehydrogenase enzyme level before treatment.
– Take each morning with breakfast, 1 × 3 d, 2 × 3 d, 3 × 3 d, 4 × 7 d, and 5 × daily thereafter
– Check CBC and liver function every month for 3 mo, then every 3 mo thereafter.
– Use for long-term control of disease • Tetracycline and niacinamide
– 500 mg of each administered tid – Use for long-term control of disease