Odontogenic Keratocyst

Etiology • A benign, aggressive developmental odontogenic cyst; may be
associated with mutation of PTCH tumor suppressor gene
Clinical Presentation • 5 to 15% of odontogenic cysts • Usually occurs sporadically as an isolated finding • Approximately 5% are associated with nevoid basal cell
carcinoma. • 5% of patients have multiple odontogenic keratocysts (OKCs)
and no syndrome

Nevoid Basal Cell Carcinoma Syndrome

Etiology • Autosomal-dominant condition • Loss of heterozygosity at chromosome 9q22.3 • Mutation of PTCH tumor suppressor gene
Clinical Presentation • Multiple jaw cysts (odontogenic keratocysts) • Numerous cutaneous basal cell carcinomas, which arise earlya
in life and are independent of sun exposure • Bifid ribs • Calcification of falx cerebri • Ocular hypertelorism • Mandibular prognathism • Broad nasal bridge • Medulloblastoma • Palmar and plantar pits

Nasopalatine Duct Cyst

Etiology • Developmental, nonodontogenic cyst • Cystic degeneration of epithelial remnants of the vestigial
nasopalatine duct
Clinical Presentation • Usually develops in adulthood • May be incidental on routine dental radiographs • Palatal mass with tenderness and drainage • Adjacent teeth are vital.
Radiographic Findings • Well-defined, medianparamedian radiolucency in anterior