Etiology • Spread of a primary malignancy to the oral cavity structures or
jaws (usually from lung, breast, prostate, colon, kidney) • Accounts for < 1% of oral malignancies
Clinical Presentation • Usually manifests in the jaws with pain and swelling • Not uncommon is loosening of teeth or pathologic jaw fracture • Soft tissue location is rare. • Most frequent sites of primary neoplasms are kidney, lung,
jaws (usually from lung, breast, prostate, colon, kidney) • Accounts for < 1% of oral malignancies
Clinical Presentation • Usually manifests in the jaws with pain and swelling • Not uncommon is loosening of teeth or pathologic jaw fracture • Soft tissue location is rare. • Most frequent sites of primary neoplasms are kidney, lung,
breast, colon, prostate, stomach • Intraosseous lesions with lytic, ill-defined radiolucencies
Microscopic Findings • As with the primary tumor • Tumor marker studies (immunohistochemical) may be necessary
to define the site of origin.
Diagnosis • Radiographic findings • Biopsy
Differential Diagnosis • Primary soft tissue tumor • Primary osseous tumor • Periodontitis (localized) • Osteoradionecrosis
Treatment • Local radiation • Combination chemoradiotherapy
Prognosis • Poor
Microscopic Findings • As with the primary tumor • Tumor marker studies (immunohistochemical) may be necessary
to define the site of origin.
Diagnosis • Radiographic findings • Biopsy
Differential Diagnosis • Primary soft tissue tumor • Primary osseous tumor • Periodontitis (localized) • Osteoradionecrosis
Treatment • Local radiation • Combination chemoradiotherapy
Prognosis • Poor