Verrucal-Papillary Lesions
Condyloma Acuminatum
Etiology • A sexually transmitted disease • Associated with human papillomavirus (HPV) types 6, 11, 16,
and 18 most often • Can result in autoinoculation of other sites via trauma • Lesions located at the site of contact/traumatic event
Clinical Presentation • Usually on nonkeratinized tissues in immunocompetent
Condyloma Acuminatum
Etiology • A sexually transmitted disease • Associated with human papillomavirus (HPV) types 6, 11, 16,
and 18 most often • Can result in autoinoculation of other sites via trauma • Lesions located at the site of contact/traumatic event
Clinical Presentation • Usually on nonkeratinized tissues in immunocompetent
patients (soft palate, lingual frenum) • Pink to whitish pink, exophytic papillary growths with pedun-
culated outline • May be solitary or multiple and variably sized, up to 2 to 3 cm • Can present as papillomatosis of upper respiratory tract
Diagnosis • Location and appearance • Demonstration of koilocytotic cellular changes on biopsy • In situ hybridization or polymerase chain reaction reveals spe-
cific HPV subtype • Electron microscopy demonstrates intranuclear virions
Differential Diagnosis • Focal epithelial hyperplasia • Multiple intraoral verruca vulgaris • Squamous papilloma
Treatment • Conservative removal
• Conventional surgery • Laser ablation
• Topical podophyllin
Prognosis • Recurrences common • Contagiousness and autoinoculation are considerations.