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Stevens-Johnson Syndrome

• Topical therapy (compounded rinses)
• Option 1 – Diphenhydramine 200 mg, viscous lidocaine 90 mL,
Maalox suspension 90 mL, distilled water 180 mL – Swish 5 mL for 2 min and expectorate 3–4 times/d
• Option 2 – Dexamethasone 100 mg, viscous lidocaine 60 mL,
diphenhydramine 200 mg, sorbitol 15 mL, Maalox suspension to 275 mL–
Swish 5 mL for 2 min and expectorate 3–4 times/d • Systemic therapy
• Prednisone 5 mg tablets #80 – Take each morning with breakfast for 16 d as 8/d × 4 d,
6/d × 4 d, 4/d × 4 d, 2/d × 2 d, stop – Will reduce disease activity as topical corticosteroids or
systemic NSAIDs are started • Acyclovir 200 mg tablets #42 (if triggered by herpes simplex
virus infection); 1 tablet every 4 h for 7 d or 1 tablet bid-tid as prophylaxis